Work

Application potential of arecoline hydrobromide for anti-Toxoplasma gondii

Year: 2025

Type: article

Abstract: Although long-term chewing areca nut may cause cancer, it is very feasible to treat human or livestock diseases in a short period of time. In this study, arecoline hydrobromide (AH), which is extracted from Areca catechu, significantly inhibited the proliferation of tachyzoites ofToxoplasma gondii (T. gondii) in vitro and in vivo. Specially,in vivo AH effectively resisted liver damage originate fromT. gondii. Furthemore, the survival and safety evaluation outcome indicated that AH can prolong survival period of mice infected with T. gondii at non-toxic and side-effect dose. Based on these advantages, AH is a candidate compound with great potential for the treatment of T. gondii infection and it may be used clinically in the future.

Source: Experimental Parasitology

DOI: 10.1016/j.exppara.2025.108946

Authors: Xu Cheng, Weifeng Yan, Jingjie Xu, Sihong Wang, Chunmei Jin

Institution: Yanbian University

Language: English

Topic: Toxoplasma gondii Research Studies

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,470