Work

Investigating the Therapeutic Effects of Melissa Officinalis on Clinical and Electro Diagnostic Findings of Patients with Type 2 Diabetes

Year: 2024

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Background: Neurological complications and glycemic control are critical to managing type 2 diabetes (T2D). This study aimed to evaluate the effects of a specific intervention with lemon balm capsules on fasting blood glucose (FBS), hemoglobin A1c (HbA1c), and nerve conduction parameters in patients with T2D. Methods: In this randomized controlled trial, 64 patients with T2D were enrolled and randomly assigned to either an experimental group (n=32) or a control group (n=32). After exclusion, 30 participants in each group completed the study. Baseline characteristics, FBS, HbA1c, and various nerve conduction parameters were measured pre- and post-intervention. Results: The experimental group demonstrated a significant reduction in FBS levels post-intervention compared to the control group (P=0.02). No significant difference was observed in HbA1c levels (P=0.08). Neurologically, the experimental group had a significant increase in tibial motor nerve action potential amplitude (P=0.001) and higher tibial motor nerve conduction velocity (P=0.03) post-intervention. Significant intra-group changes were also noted in peroneal motor nerve action potential amplitude (P=0.002) and sural sensory nerve potential amplitude (P=0.009). Finally, no significant differences were found in ulnar and median nerve parameters or F-wave latency. Conclusion: The intervention with lemon balm led to significant improvements in FBS levels and certain nerve conduction parameters in patients with T2D, indicating potential benefits for metabolic control and nerve function.

Source: Biomedical Research Bulletin

DOI: 10.34172/biomedrb.2024.22