Multicentric plasma cell variant of Castleman disease – A case reportMulticentric Plasma Cell Variant of Castleman Disease: A Case Report
Year: 2024
Type: article
Study design: Case Report
Abstract: Castleman disease (CD) is a lymphoproliferative disorder with markedly different presentations and clinical courses. The manifestations of this rare disease depend on the distribution and pathologic subtype. The histological variants of CD include the hyaline vascular variant and the plasma cell variant, with the former constituting about 90% of cases. Clinically, the unicentric form of CD is associated with a better prognosis, while multicentric CD is linked to a long-term poor outcome with an increased risk of second malignancies. Histopathologic examination of the involved lymph nodes remains the mainstay of diagnosis due to the clinical heterogeneity of the disease. We present the case of a 64-year-old male who was evaluated for bilateral inguinal lymphadenopathy, with a PET scan showing multiple hypermetabolic intra-abdominal lymph nodes. In view of a strong clinical suspicion of lymphoma, excision biopsy of the left inguinal lymph node was performed and sent for histopathological examination.
DOI: 10.21276/apalm.3359
Authors: Anitha Wilson, Elizabeth Joseph, Asha Peedikayil Punnoose, Minnu Elza Varghese, Ajmal T
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409688568