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Impact of AstraZeneca COVID-19 Vaccination on Coagulation and Gene Expression: A Molecular and Clinical Study

Year: 2025

Type: article

Abstract: This case-control study investigated the effects of the AstraZeneca COVID-19 vaccine on coagulation parameters in a cohort of 102 individuals, revealing a significant increase in activated partial thromboplastin time (aPTT) among vaccinated individuals (34.233±0.653 seconds vs 28.196±0.657 seconds, p<0.0001), which correlated with increased TMPRSS2 expression (r=-0.325, p=0.0202). The findings have important clinical implications, suggesting that vaccinated individuals, particularly those with underlying coagulopathies, may require closer monitoring for thrombotic events. The observed changes in aPTT and TMPRSS2 expression may have significant implications for patients with pre-existing coagulation disorders or those at risk of thrombotic events, emphasizing the need for vigilant monitoring and personalized care in vaccinated individuals, and highlighting the importance of further research to inform evidence-based guidelines for COVID-19 vaccination.

DOI: 10.9734/ijr2h/2025/v8i1171

Authors: Erens Spiff Ekprikpo, Stella Urekweru Ken-Ezihuo, Beauty Eruchi Echonwere-Uwikor, Zaccheaus Awortu Jeremiah

Institution: Rivers State University

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4409697772

FWCI:

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