Work

The 730 nm Picosecond Titanium Sapphire Laser for Treatment of Kratom‐Induced Hyperpigmentation

Year: 2025

Type: article

Abstract: OBJECTIVES: This case series reports the use of the 730-nm picosecond titanium-sapphire laser in the treatment of kratom-induced hyperpigmentation, a dermatological side effect associated with the use of Mitragyna speciosa, which remains poorly understood. METHODS: A series of patients with kratom-induced hyperpigmentation were treated using the 730-nm picosecond titanium-sapphire laser. Treatment outcomes were documented by assessing the degree of pigmentation improvement and noting the occurrence of any adverse effects or recurrence of hyperpigmentation. RESULTS: All patients showed significant improvement in the appearance of hyperpigmentation following treatment. No adverse effects or recurrence of hyperpigmentation were observed during the follow-up period. CONCLUSIONS: This case series represents the first documented use of the 730-nm picosecond titanium-sapphire laser for treating kratom-induced hyperpigmentation. The laser's precision and minimal tissue disruption suggest it as a promising treatment option for this challenging dermatological side effect.

Source: Lasers in Surgery and Medicine

DOI: 10.1002/lsm.70019

Authors: Alanoud A. Alhadyani, Christen Samaan, Girish S. Munavalli

Institutions: Dermatology, Laser & Vein Specialists of the Carolinas, Johns Hopkins University, Wake Forest University Health Sciences, Wake Forest University

Language: English

Topic: Dermatologic Treatments and Research

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,620