β‐Quaternary α‐Amino Acids via Iridium‐Catalyzed Branched and Enantioselective Hydroalkylation of 1,1‐Disubstituted Styrenes
Year: 2025
Type: article
Abstract: A cationic Ir(I)‐complex modified with the chiral diphosphine DM‐SEGPHOS mediates the hydroalkylation of diverse α‐methyl styrenes with N‐aryl glycine derivatives. The processes occur with complete branched selectivity and high enantioselectivity. Styrenes possessing higher α‐alkyl substituents also participate to provide the targets with moderate to excellent levels of diastereoselectivity. The products are readily advanced to β‐quaternary α‐amino acids that are inaccessible or cumbersome to access by other means. In broader terms, the study demonstrates how catalyst controlled C─H additions across alkenes can be used to execute the by‐product‐free construction of contiguous acyclic trisubstituted and quaternary centers.
Source: Angewandte Chemie
Institution: University of Liverpool
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $5,790
OpenAlex ID: W4409701109