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Activation and inhibition of Notch signaling facilitate proliferative regeneration of sensory cells in adult mice

Year: 2025
Type: article
Abstract: Due to the limited regenerative capacity in adult mammals, the loss of vestibular hair cells (HCs) leads to balance disorders. In this study, we chronologically reprogrammed adult vestibular supporting cells (SCs) via bimodal regulation of Notch signaling, mimicking dynamic changes in Notch signaling during inner ear development. We found that activating Notch signaling stimulated SC proliferation in damaged adult utricles, priming these cells with the potential to regenerate sensory HCs. Subsequent inhibition of Notch signaling removed lateral inhibition barriers, promoting the transition from proliferating SCs to HCs. Our findings underscore the crucial role of Notch signaling in promoting vestibular HC regeneration.
DOI: 10.1002/eer3.70008
Authors: Shan Zeng, Tao Jiang, Zhengyi Chen, Huawei Li, Luo Guo, Wenyan Li
Institutions: Fudan University, Eye & ENT Hospital of Fudan University, State Key Laboratory of Medical Neurobiology, Frontiers Center for Brain Science of the Ministry of Education, Massachusetts Eye and Ear Infirmary, Harvard University, Shanghai Medical College of Fudan University
Language: English
Subfield: Sensory Systems
Open Access status: diamond
OpenAlex ID: W4409703469
FWCI:
Cites: 39
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Related to: 10