Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Sepsis is an organ dysfunction that impairs response to infection. Inflammatory biomarkers have been used to diagnose and monitor sepsis. The aim of the present study was to determine the role of immature granulocytes (IGs) in monitoring sepsis treatment. METHODS: This two-center, prospective, observational study included patients diagnosed with sepsis according to the Sepsis-3 criteria, who were followed-up in the adult intensive care units of the Bolu Izzet Baysal State Hospital and Bolu Izzet Baysal Training and Research Hospital (Bolu Merkez/Bolu, Türkiye). Laboratory investigation results, demographic information, treatment responses, and mortality were recorded. Patients were divided into 2 groups according to treatment: appropriate (group 1); and inappropriate (group 2). Differences in the number of IGs and IG% were compared. Differences with P < 0.05 were considered to be statistically significant for all analyses. RESULTS: The study included 87 patients from 2 centers. The most common comorbidities were hypertension (54%) and 28-day mortality (37.9%). Empirical antibiotic therapy (43.7%) was appropriate for 38 patients (group 1) and 49 patients when the treatment was incorrect or inadequate (group 2). There were no significant differences between the groups in terms of laboratory investigation results on the day of treatment initiation. IG count and IG% on day 3 of treatment were significantly higher in group 2. Mortality was higher in patients with a high IG count (IG %) and in group 2. CONCLUSION: IG% was a simple, inexpensive, and useful test for monitoring sepsis treatment and, in addition, IG count was also effective in predicting mortality.
Source: BMC Anesthesiology
Authors: Mustafa Deniz, Zahide Sahin Yildirim, Zuleyha Erdin, Murat Alisik, Ridvan Erdin, Mustafa Yildirim
Institution: Bolu Abant İzzet Baysal University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,190
OpenAlex ID: W4409709876