Work

Arterial cardiovascular outcomes and venous thromboembolism in patients with primary Sjögren’s syndrome: a Danish cohort study

Year: 2025

Type: article

Abstract: OBJECTIVE: To evaluate whether atherosclerotic cardiovascular disease outcomes, venous thromboembolism, heart failure, and cardiovascular mortality are elevated in patients with primary Sjögren's syndrome (pSS) compared with a matched cohort from the general population. METHODS: We conducted a nationwide population-based cohort study including all patients with a pSS diagnosis from 1996 to 2017 in Denmark, matched with a comparison cohort on age, gender, and calendar year. The cumulative incidence of each outcome was computed using hospital contact diagnoses as the end point. We used Cox regression to calculate hazard ratios (HRs) for the endpoints, adjusted for potential confounding factors. RESULTS: The study included 4697 pSS patients (median age 57 years, 87% women) and 46 970 persons in a comparison cohort followed for a median of 7.6 years (maximum 23 years). After confounder adjustment, pSS was associated with elevated rates of myocardial infarction (adjusted hazard ratio [aHR] 1.23; 95% confidence interval [CI] 1.01-1.50), ischaemic stroke (aHR 1.31; 95% CI 1.14-1.52) and haemorrhagic stroke (aHR 1.51; 95% CI 1.13-2.03), peripheral artery disease (aHR 1.44; 95% CI 1.13-1.83), and venous thromboembolism (aHR 1.57; 95% CI 1.33-1.85). Cardiovascular death (aHR 1.11; 95% CI 0.95-1.30) and heart failure (aHR 1.17; 95% CI 0.99-1.39) were slightly elevated in patients with pSS. CONCLUSION: This study provides firm evidence that pSS is associated with increased risk of all atherosclerotic cardiovascular outcomes and venous thromboembolism, and highlights the importance of managing cardiovascular risk factors in these patients.

Source: Lara D. Veeken

DOI: 10.1093/rheumatology/keaf210

Authors: Pierre Loiseau, Aurélie Mailhac, Pierre Duhaut, Reimar W Thomsen

Institutions: Aarhus University, Aarhus University Hospital, Centre Hospitalier Universitaire Amiens-Picardie, Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires, Université de Picardie Jules Verne

Language: English

Topic: Salivary Gland Disorders and Functions

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,597