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Epidermolysis bullosa acquisita in a 53-year-old female with extensive cutaneous and mucosal involvement

Year: 2025

Type: article

Abstract: Epidermolysis bullosa acquisita (EBA) is a rare autoimmune blistering disorder characterized by subepidermal blisters, typically caused by an autoimmune response against type VII collagen, a key structural component of the dermal-epidermal junction. Here, we report a case of EBA in a 53-year-old female with extensive multiple bullae, erosions over extremities, trunk, genitaila. HPE revealed a sub-epidermal blister with fibrin, neutrophils, and some eosinophils, DIF showed IgG positivity (+3) in a linear pattern along the dermal-epidermal junction. enzyme immunoassay (EIA) for anti-collagen type VII antibodies was positive. Based on clinical features and investigations patient is diagnosed as Epidermolysis Bullosa Acquisita. She was treated with systemic steroids and topical steroids with gradual tapering. This case highlights the importance of early diagnosis and treatment in managing this condition effectively.

Source: International Journal of Research in Dermatology

DOI: 10.18203/issn.2455-4529.intjresdermatol20251054

Authors: Reddy Siva Sai Manikanta, K. V. T. Gopal, P. V. Krishnam Raju, N. Krishna Sagar

Language: English

Topic: Autoimmune Bullous Skin Diseases

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409711806

FWCI:

Cites: 7

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Related to: 10