Work

Relationship Between Serum Hydrogen Sulfide and Ferritin Levels in Type 2 Diabetes Mellitus: A Retrospective Study at a Tertiary Hospital in Eastern India

Year: 2025

Type: article

Abstract: Introduction: Diabetes mellitus, one of the widespread endocrine disorders, is characterized by hyperglycemia. Hydrogen sulfide (H2S), a signaling gas transmitter, is involved in carbohydrate metabolism. The pathophysiology of β-cell dysfunction in type 1 and 2 diabetes may be significantly affected by alterations in the H2S balance. Diabetes mellitus causes an increase in ferritin, an acute-phase reactant. Aims and objectives: This study aims to investigate the relationship between serum H2S and ferritin levels in patients with type 2 diabetes. Methodology: Spectrophotometric measurements of serum H2S were made using a lab-standardized technique. Enzyme-linked immunosorbent assay (ELISA) was used with standardized kits (BioRad Laboratories, Hercules, CA, USA) to determine serum ferritin levels. Results: Compared to the control group, type 2 diabetic patients had significantly greater serum ferritin levels and significantly lower H2S levels. H2S and ferritin levels are negatively correlated among cases and controls. Conclusion: The negative connection between ferritin and H2S levels indicates that oxidative stress plays an important part in the beginning and development of diabetes mellitus.

Source: Cureus

DOI: 10.7759/cureus.82815

Authors: Pinaki Saha, Bikramaditya Mukherjee, Sayantan Dasgupta, Santanu Sen, Utpal Biswas

Institutions: Manipal Academy of Higher Education, Manipal-Tata Medical College, Jamshedpur, North Bengal Medical College and Hospital, Calcutta National Medical College and Hospital, Medical College and Hospital, Kolkata

Language: English

Topic: Sulfur Compounds in Biology

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409712032