Work

Comparative effects of extracellular vesicles and liposomal nanocarriers on bleomycin-induced stress in A549 human adenocarcinoma cells

Year: 2025

Type: article

Abstract: ) effectively attenuated bleomycin-induced EMT, inhibited cell migration, suppressed profibrotic TGF-β1, lowered intracellular ROS and upregulated glutathione peroxidase 4 (GPX4). Importantly, the innate bioactive cargo of the naturally derived nanoalgosomes exhibited comparable effects to the liposome therapeutic formulations in mitigating bleomycin-induced stress in A549 cells.

Source: Biomedicine & Pharmacotherapy

DOI: 10.1016/j.biopha.2025.118081

Authors: Thomas Conlon, Maximilian Schaaf, Ana Mateos-Maroto, Sabrina Picciotto, Svenja Morsbach, Giorgia Adamo, Shutian Si, Ingo Lieberwirth, Christine Rosenauer, Katharina Landfester, Antonella Bongiovanni, Nicolas Touzet

Institutions: Atlantic Technological University, Max Planck Institute for Polymer Research, National Research Council, Institute for Biomedical Research and Innovation

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,610

Funders: Horizon 2020 Framework Programme, Horizon 2020

Award: G3536449958

OpenAlex ID: W4409716206

FWCI: 1.512

Cites: 60

Cited by: 6

Related to: 10