Musculoskeletal disorders in type 1 diabetes: Clinical phenotyping and associations with quality of life and glucose control - The French SFDT1 cohort study
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Musculoskeletal disorders (MSDs) are common, but overlooked, complications of type 1 diabetes mellitus (T1DM). This study aims to describe MSD phenotypes (clinical, lifestyle, socio-economic) in adults with T1DM. METHODS: We analyzed adult participants in the SFDT1 cohort study. We assessed the following MSDs: stress fractures, non-traumatic upper-limb disorders, and entrapment syndromes. We performed a cross-sectional analysis of the association between MSDs and various factors. After applying multiple imputations for missing data, we computed logistic regression models with progressive adjustments on confounding factors. RESULTS: Of 1832 participants (53 % men, median age 38 (IQR 22) years), 34 % reported at least one personal history of MSD: 8 % for stress fractures, 24 % for upper-limb disorders and 15 % for entrapment syndromes. A higher prevalence of MSDs was found in women, with aging and with diabetes duration. In a fully adjusted model, we observed a positive association between current smoking (OR [95 %CI] = 1.50 [1.14;1.97]), non-excessive alcohol consumption (1.45 [1.14;1.85]), neuropathy (1.70 [1.35;2.15]), retinopathy (1.30 [1.02;1.65]), use of automated insulin delivery systems (1.53 [1.06;2.21]) and MSDs. MSDs were associated with reduced global quality of life (0.97 [0.95;0.98]). MSDs were not associated with HbA1c, social vulnerability or physical activity. CONCLUSION: We have shown that MSDs are found in 1 in 3 people with T1DM. They are associated with several lifestyle factors, diabetes complications and the use of automated insulin delivery systems. MSDs should be considered in the T1DM assessment to optimize quality of life.
Source: Diabetes & Metabolism
Authors: Noémie Topalian, Sylvie Picard, Jean-Pierre Riveline, Dulce Canha, Jean-Baptiste Julla, Sandrine Lablanche, Laurence Salle, Emmanuel Sonnet, Aurélie Berot, Didier Gouet, Kalliopi Bilariki, Chloé Amouyal, Lucien Marchand, Sophie Borot, Nicolas Chevalier, Isabela Banu, Emmanuelle Sokol, Emmanuel Cosson, Guy Fagherazzi, Gloria Aguayo
Institutions: Luxembourg Institute of Health, Centre National de la Recherche Scientifique, Inserm, Université Paris Cité, Institut Necker Enfants Malades, Hôpital Lariboisière, University of Luxembourg, Université Grenoble Alpes, Centre Hospitalier Universitaire de Limoges, Institut de Recherche pour le Développement, Université de Limoges, Centre Hospitalier Régional Universitaire de Brest, Centre Hospitalier Universitaire de Reims, Centre Hospitalier de La Rochelle, Centre Hospitalier Compiègne-Noyon, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Centre Hospitalier Saint-Joseph Saint-Luc, Université de Franche-Comté, Université Côte d'Azur, Hôpital Paris Saint-Joseph, Conservatoire National des Arts et Métiers, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Université Sorbonne Paris Nord, Sorbonne Paris Cité, Hôpital Avicenne, Equipe de Recherche en Epidémiologie Nutritionnelle, Centre de Recherche Épidémiologie et Statistique
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,490
OpenAlex ID: W4409716986