Work

Nucleophilic Additions of Organolithium Reagents to Heterocyclic Aldimines

Year: 2025

Type: article

Abstract: The addition of alkyllithium reagents to heterocyclic aldimines is described. This method is a straightforward two-step procedure from the starting aldehyde and amine with one purification. The ability to use unprotected indole carboxaldehydes as substrates is a key feature of this method that make it an attractive way to synthesize the corresponding amine products.

Source: Synlett

DOI: 10.1055/a-2593-6446

Authors: Timothy J. Barker, Justin Baek, Walker A. Hoisington, Evelyn S. Galgano, Ethan H. Schneider

Institution: College of Charleston

Language: English

Topic: Coordination Chemistry and Organometallics

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: College of Charleston, National Institutes of Health, National Institute of General Medical Sciences, National Center for Research Resources