Clinical and paraclinical features and their correlation with genotype and subgenotype c of hepatitis b virus in patients with hepatocellular carcinoma
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: To describe the clinical and paraclinical characteristics and analyze their association with hepatitis B virus (HBV) genotypes and subgenotypes in patients with hepatocellular carcinoma (HCC). Subject and method: A cross-sectional study with prospective data collection was conducted on 129 patients diagnosed with HCC by histopathology, having pure HBV infection, and with complete HBV genome sequencing from January 2022 to December 2024. Result: Among 129 HBV-related HCC patients, genotype B (55.8%) was more prevalent than genotype C (44.2%). Genotype C was associated with older age (61.3 vs. 55.8 years, p<0.05), higher cirrhosis prevalence (78.9% vs. 55.6%, p<0.05), elevated viral load (6.8 vs. 5.1 log10 IU/mL, p<0.05), and more severe liver dysfunction. Subgenotype C1 (24.8%) demonstrated more aggressive tumor features, including larger tumor size (68.8% >5cm) and vascular invasion (43.8%) compared to B2. Multivariate analysis identified cirrhosis (OR=3.8) and high HBV DNA (>6 log10 IU/mL, OR=4.5) as independent predictors for genotype C. Conclusion: Genotype B (55.8%) predominates over genotype C (44.2%) in HBV-related HCC patients, with genotype C showing more severe clinical manifestations and poorer prognosis. Cirrhosis and high viral load serve as independent predictors for genotype C.
DOI: 10.63583/yk82gz64
Authors: Tran Van Hieu, Duong Thi Minh Thien
Language: English
Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4409723381