Work

Synthesis and biological evaluation of chalcone derivatives of oxazole-pyrimidines as anticancer agents

Year: 2025

Type: article

Abstract: We have developed a new library of chalcone derivatives of oxazole-pyrimidines ( 16a-j ) and their structures were confirmed by analytical data. Further, in vitro anticancer activity of the newly prepared compounds 16a-j was assessed against a panel of four human cancer cell lines such as human breast cancer (MCF-7), human lung cancer (A549), human colon cancer (Colo-205) and human ovarian cancer (A2780) by using of MTT method. All the screened compounds displayed remarkable anticancer activity as compared with etoposide used as positive control. Among them, five compounds 16a, 16 g, 16 h, 16i & 16j possessed more potent activity. Particularly, one compound 16j with 3,5-dinitro group showed superior activity.

Source: Results in Chemistry

DOI: 10.1016/j.rechem.2025.102294

Authors: Divya Komirishetti, Tasqeeruddin Syed, Vasantha Mittapelli

Institutions: Mahatma Gandhi University, Nalgonda, King Khalid University

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,870