Work

Estrogen regulation of the nucleus accumbens as a gateway to understanding menopause associated metabolic dysfunction

Year: 2025

Type: article

Abstract: The nucleus accumbens (NAc) may be a link between metabolic and behavioral changes due to menopause. Loss of estrogen (E2) activation in the NAc might cause reduced physical activity and adipose tissue dysfunction. We review potential mechanisms by which NAc might communicate with adipose tissue and how menopause may impact this pathway. A better understanding of the NAc-adipose tissue axis will pave the way for improved treatments in menopausal women.

Source: npj Women s Health

DOI: 10.1038/s44294-025-00071-1

Authors: Cheryl S. Rosenfeld, Victoria J. Vieira-Potter

Institution: University of Missouri

Language: English

Topic: Estrogen and related hormone effects

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,190