Work

Use of 68Ga-labeled Macroaggregated Albumin Particles for Selective Internal Radiation Therapy (SIRT) Dosimetry and Treatment Planning

Year: 2025

Type: article

Abstract: In October 2024, Europe again experienced a period of shortage of technetium-labeled tracers. In order not to delay time-critical treatments of liver tumors, we turned to 68 Ga-labeled macroaggregated albumin particles ([ 68 Ga]Ga-MAA) as already used for lung perfusion PET imaging for selective internal radiation therapy (SIRT) dosimetry and treatment planning. Labeling was performed under GMP conditions and could be applied for SIRT planning in one patient. Post-therapy dosimetry based on [ 90 Y]microsphere PET/CT demonstrated excellent agreement. Dosimetry and treatment planning with [ 68 Ga]Ga-MAA should be considered as a viable alternative to [ 99m Tc]Tc-MAA SPECT/CT and could be considered for routine use.

Source: Clinical Nuclear Medicine

DOI: 10.1097/rlu.0000000000005852

Authors: Christian Goetz, Michael Christian Doppler, Mohamed Aymen Omrane, Wibke Uller, Philipp Tobias Meyer

Institutions: University of Freiburg, University Medical Center Freiburg

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4409731685

FWCI:

Cites: 5

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Related to: 10