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Beyond immunosuppression: decoding systemic immune dysregulation in ICU-acquired pneumonia

Year: 2025
Type: article
Abstract: Extract Intensive care unit (ICU)-acquired pneumonia, either ventilator-associated or hospital-acquired, represents a major clinical challenge that is associated with high mortality, prolonged hospitalisations, and increased cost [1, 2]. Prior research has focused on immunosuppression as the primary driver of infection susceptibility; however, clinical trials of immunostimulatory agents have been largely unsuccessful, suggesting that the pathogenesis of ICU-acquired pneumonia is more complex than previously appreciated [3–5].
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W4409733219
FWCI: 2.239
Cites: 30
Cited by: 3
Related to: 10