Temporal mineralocorticoid receptor activation regulates the molecular clock and transcription of cardiovascular disease modulators in myeloid cells
Year: 2025
Type: article
Abstract: Mineralocorticoid receptor (MR) signaling dynamically regulates the circadian clock and inflammatory gene expression in myeloid cells. Using myeloid-specific MR knockout mice, we identified disrupted time-of-day expression of core clock and inflammatory genes, with sex-based differences in response. These findings reveal novel MR-circadian clock interactions in immune cells and suggest a time- and sex-dependent mechanism by which MR shapes macrophage phenotype and potentially cardiac inflammation.
Authors: Seamus Heanue, Monica Kanki, James Morgan, Judy Ng, Timothy J. Cole, Graeme Lancaster, David W. Ray, Morag J. Young
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4409735882