Work

Vaccination against influenza viruses annually: Renewing or narrowing the protective shield?

Year: 2025

Type: review

Abstract: Annual vaccines are recommended for the seasonal influenza virus. While yearly updates to the vaccine are necessary due to the constant evolution of influenza viruses, some studies have suggested repeat vaccination may result in a reduction in vaccine effectiveness in subsequent years. This review examines the available evidence that repeated annual influenza virus vaccination may have effects on future vaccine responses, and it synthesizes the available data with studies that may indicate potential immunological mechanisms underlying these effects. The goal is to examine the available literature to determine whether these mechanisms can be subverted to improve seasonal influenza virus vaccine efficacy.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20241283

Authors: Hanover C. Matz, Ali H. Ellebedy

Institution: Washington University in St. Louis

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Pfizer, Moderna, National Institutes of Health, National Institute of Allergy and Infectious Diseases