Work

Toward an ex vivo preparation for studies of the cochlear active process in mammals

Year: 2025

Type: article

Abstract: concentration. We also maintained a constant temperature in order to stabilize the experimental conditions. Most critically, by introducing a mechanism to adjust the pressure in the endolymphatic compartment, we were able to explore how variations in transepithelial pressure influence the electrical response. These changes enabled us to reliably measure compressive nonlinearities with a one-third power law similar to that observed from cochleas in vivo and consistent with the behavior of a dynamical system operating near a Hopf bifurcation.

Source: Hearing Research

DOI: 10.1016/j.heares.2025.109288

Authors: Francesco Gianoli, Rodrigo Alonso, Brian Fabella, A.J. Hudspeth

Institutions: Howard Hughes Medical Institute, Rockefeller University

Language: English

Topic: Hearing, Cochlea, Tinnitus, Genetics

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,130

Funder: Howard Hughes Medical Institute