Work

Nickel/aluminium oxide as a sustainable and cost-effective catalyst for the Sonogashira coupling reaction

Year: 2025

Type: article

Abstract: In our study, we report a cost-effective and sustainable Sonogashira coupling reaction with Nickel supported on alumina (Ni/Al 2 O 3 ) as a palladium-free catalyst. The procedure effectively couples phenylacetylene and 2-ethynylpyridine with various aryl iodides under optimized conditions and provides a greener route by reducing hazardous waste , cost-effectiveness, and eliminating toxic palladium catalysts. The simplicity of catalyst preparation and reusability of the catalyst make the procedure amenable to large-scale applications in keeping with green chemistry principles.

Source: Tetrahedron

DOI: 10.1016/j.tet.2025.134678

Authors: Priya C. Saroj, Manjunath S. Lokolkar, Sai Srinivas Ponugoti, Priyanka R. Ugale, Bhalchandra M. Bhanage, Shreerang V. Joshi

Institution: Institute of Chemical Technology

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: hybrid

Estimated APC paid: $3,680