Adaptation and validation of the Mexican Quality of Life Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA)
Year: 2025
Type: article
Abstract: BACKGROUND: Growth hormone deficiency (GHD), caused by decreased secretion of growth hormone by the pituitary, has clinical repercussions that impact body composition, metabolic parameters, and can have a negative impact on quality of life. The Quality of Life in Adults with Growth Hormone Deficiency (QoL-AGHDA) is a patient-reported outcome measure used to assess the quality of life of adults with GHD. OBJECTIVE: The objective of this study was to validate the QoL-AGHDA for use in Mexico. Materials and methods: First phase: Translation of the QoL-AGHDA into Spanish as spoken in Mexico. Face and content validity were assessed through 10 Cognitive debriefing interviews. Second phase: The Mexican version of the QoL-AGHDA was administered to 40 patients on two occasions for subsequent analysis. The distributional properties of the measure were explored through descriptive statistics. Cronbach's α was calculated for internal consistency, and Spearman's correlation coefficient was used to assess reliability. RESULTS: The QoL-AGHDA for Mexicans showed high internal consistency, with Cronbach's α coefficients of 0.91 and 0.92. Test-retest reliability was excellent, with a Spearman's correlation coefficient of 0.95. Conclusion: The Mexican adaptation of the QoL-AGHDA demonstrated good psychometric properties, supporting its use in future studies to assess quality of life in adults with GHD in Mexico.
Source: Gaceta Médica de México
Authors: Jesús Cajigas-Silva, Jeanette Thorpe, Isobel Spray, Mariusz T. Grzeda, Lesly A. Portocarrero-Ortiz
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409740558