Impact of triglyceride glucose - Body mass index on depression risk in Chinese middle-aged and elderly adults: Evidence from a large-scale study
Year: 2025
Type: article
Abstract: • Our study is the first large-scale investigation utilizing Chinese population data to explore the association between TyG-BMI and depression, revealing a distinct L-shaped relationship. • Specifically, when TyG-BMI was below 200, depressive risk progressively decreased with increasing TyG-BMI levels. However, no significant association was observed once TyG-BMI exceeded 200. • These findings provide clinicians with novel insights into the metabolic-psychiatric interplay, emphasizing the importance of monitoring TyG-BMI thresholds (around 200) for early depression risk stratification. Current literature lacks evidence to characterize the relationship between the triglyceride glucose - body mass index (TyG-BMI) and depression. Therefore, this study aimed to elucidate the potential association between TyG-BMI and depression risk in a Chinese middle-aged and elderly population. The study utilized data from the China Health and Retirement Longitudinal Study (CHARLS) conducted in 2011, which included 17,708 participants. We used multifactorial logistic regression modeling to investigate the relationship between TyG-BMI and depression in Chinese adults, using smoothed curve fitting to assess the nonlinear relationship between them. In addition, we performed sensitivity and subgroup analyses to verify the robustness of the results. A total of 9328 participants were included in our study, After adjusting for all potential covariates, participants with higher levels of TyG-BMI had a lower risk of depression compared to Q1, the adjusted OR (95 % CI) values were Q2 (OR: 0.84, 95 % CI: 0.74–0.96, p = 0.009), Q3 (OR: 0.75, 95 % CI: 0.65–0.86, p < 0.001), and Q4 (OR: 0.67, 95 % CI: 0.57–0.79, p < 0.001). The association between TyG-BMI and depression exhibited an L -shaped curve (nonlinear, p = 0.004). When TyG-BMI <200, Increased TyG-BMI was associated with a significantly lower risk of depression (OR = 0.87 [95 %CI:0.82–0.93], p < 0.001). However, there was no association between TyG-BMI and depression when TyG-BMI ≥200 (OR = 0.96 [95 %CI:0.91–1.02], p = 0.22). The connection between TyG-BMI and depression in Chinese adults is L -shaped, with an inflection point around 200.
Source: Physiology & Behavior
Authors: Bohong Hu, Dandan Yu, Guixiang Guo, Fangchao Wan, Hongjuan Liu
Institution: Central South University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,500
OpenAlex ID: W4409744626