Exploring the prognostic value of the novel nutritional index for in-hospital mortality in acute coronary syndrome: a sex-specific analysis
Year: 2025
Type: article
Abstract: Background Emerging evidence suggests that nutritional status plays a pivotal role in determining the prognosis of patients with acute coronary syndrome (ACS). This study aimed to investigate the relationship between a novel nutritional index, Triglycerides × Total Cholesterol × Body Weight Index (TCBI), and short-term prognosis in patients with ACS. Methods A retrospective study was conducted using data from 5,277 ACS patients admitted to intensive care units of 208 United States hospitals in the eICU Collaborative Research Database (eICU-CRD) in 2014 and 2015. Patients were divided into three groups based on TCBI tertiles: Group 1 (< 1017.97), Group 2 (1017.97–2069.02), and Group 3 (> 2069.02). Results Multivariate logistic regression analysis showed that after adjusting for 17 confounding variables, higher TCBI had significantly lower in-hospital mortality [Tertile 3 vs Tertile 1: OR (95% CI): 0.67 (0.48, 0.94), p = 0.019]. This relationship was significant in the male subgroup but not in the female subgroup. The association between TCBI and in-hospital mortality was more pronounced in male patients and those with blood pressure > 140 mmHg. Subgroup analysis revealed a significant interaction between sex and the predictive value of TCBI ( p for interaction < 0.05). Conclusion Higher TCBI was independently associated with decreased in-hospital mortality in ACS patients, particularly in male patients. TCBI, as a novel nutritional index, may serve as a practical tool for risk stratification and personalized management of ACS patients.
Source: Frontiers in Medicine
Authors: Guimei Li, Shujuan Li
Institution: Inner Mongolia Medical University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4409746922