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Editorial: Molecular innate immunity in aquatic animals and their response to epidemic diseases

Year: 2025

Type: editorial

Abstract: In addition, another significant study examined the effects of mycotoxins on the innate immune system of aquatic animals. Zheng et al. explored the immunotoxicity of ochratoxin A (OTA) in zebrafish, focusing on its impact on innate immunity. The study found that OTA exposure inhibited embryonic development, reduced neutrophil and macrophage numbers, and impaired immune cell migration during fin regeneration.Transcriptome analysis showed that OTA upregulated the apoptosis pathway mediated by anxa1a and anxa1d in neutrophils. Moreover, aesculetin was shown to mitigate the immunotoxic effects of OTA, indicating its potential as a therapeutic agent. These studies have not only provided new theoretical foundations for aquatic animal immunology but also offered valuable guidance for aquaculture practices. The integration of environmental sensors with gene-editing technologies holds the potential to achieve a dual breakthrough in dynamic dissolved oxygen control and the breeding of disease-resistant varieties, promoting the development of the aquaculture industry toward greater intelligence and sustainability.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2025.1608192

Authors: Hu Lu, Zhiwei Liao, Jiejie Sun, Linwei Yang, Hengwei Deng

Institutions: Hainan University, The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Dalian Ocean University, Fujian Agriculture and Forestry University

Language: English

Topic: Aquaculture disease management and microbiota

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801

OpenAlex ID: W4409747056

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