Work

Phytochemical profiling with cytotoxic and genotoxic potential of green tobacco leaf extract

Year: 2025

Type: article

Abstract: Tobacco (genus Nicotiana), primarily cultivated for commercial use, poses significant occupational health risks, particularly during its green leaf stage. This study investigates the cytotoxic and genotoxic effects of green tobacco (Nicotiana tabacum L.) through phytochemical analysis using GC-MS and cytological assays on Allium cepa. GC-MS results revealed major compounds including nicotine (42.55%), naphthalene (34.08%), neophytadiene, phytol, and various methyl esters. In cytological duration dependent exposure of root tip meristematic cell and young flower buds in green leaf extracts showed reduced mitotic index as well as meiotic index and different types of chromosomal abnormalities such as stickiness, bridges, laggards, and micronuclei formation.

Source: World Journal of Biology Pharmacy and Health Sciences

DOI: 10.30574/wjbphs.2025.22.1.0412

Authors: Shalini Mehta, Swati Sandhya

Institution: Ranchi University

Language: English

Topic: Carcinogens and Genotoxicity Assessment

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Indian Agricultural Research Institute