Work

Effect of Pulsed-Field Ablation on Human Coronary Arteries

Year: 2025

Type: article

Abstract: BACKGROUND: Pulsed-field ablation (PFA) is known to cause acute coronary spasm. Whether this translates into long-term coronary artery stenosis is unknown. OBJECTIVES: This study sought to evaluate changes in coronary artery after PFA for atrial flutter. METHODS: After pulmonary vein isolation with PFA (Farapulse; Boston Scientific), patients undergoing ablation of the mitral isthmus (MI) or cavotricuspid isthmus (CTI) were included. They underwent coronary angiography and optical coherence tomography (OCT) before and immediately after ablation. Bolus intracoronary nitroglycerine was given before and throughout ablation. Three months after ablation, patients underwent repeated OCT. RESULTS: ; P < 0.01), or 10.1% (Q1-Q3: 4.7%-16.2%). These changes were not observed in a predetermined reference site remote from the ablation target. CONCLUSIONS: PFA of the CTI and MI is associated with acute spasm, and mild narrowing of the coronary arteries at 3 months. Although intracoronary vasodilator therapy may prevent or treat acute spasm, the risk of arterial stenosis remains, calling for heightened vigilance and long-term follow-up.

Source: JACC. Clinical electrophysiology

DOI: 10.1016/j.jacep.2025.03.014