Year: 2025
Type: article
Abstract: N-Benzylhydroxylamine hydrochloride serves as a critical intermediate in organic synthesis, yet traditional synthesis methods often face significant safety risks and high production costs. In this work, we developed a continuous synthesis process for N-benzylhydroxylamine hydrochloride, achieving an overall yield of 75% under mild and safe reaction conditions. Additionally, the implementation of solvent recovery and the recycling of hydroxylamine hydrochloride reduced the production cost to approximately $10 per kilogram. These advancements underscore the economic and practical viability of this method for large-scale industrial applications.
Source: Chemistry
Authors: Xiaoguang Chen, Ke Chen, Ke Chen, Guoxian Cai, Haoyue Xiang, Kai Chen, Kai Chen, Hua Yang
Institution: Central South University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,172
OpenAlex ID: W4409763875