Work

An Electrochemical Strategy for Chalcogenation of closo -Dodecaborate (B 12 H 12 ) 2– Anion

Year: 2025

Type: article

Abstract: Advancements in thermal neutron generation technologies within clinical environments have led to a renewed interest in developing boron-containing compounds for boron neutron capture therapy (BNCT). Previous syntheses of several key boron cluster-based therapeutics with clinical relevance are low-yielding and have complicated workup procedures. Using electrolytic methods, we report the in situ oxidation of pseudohalides, –SCN and –SeCN, to synthesize pseudohalogenated products, B12H11YCN2– (Y = S or Se). Further, these compounds can be reduced to their respective thiol or selenol, BSH or BSeH, which are exceedingly nucleophilic and able to form zwitterionic sulfonium and selenonium compounds using alkyl-based electrophiles. The newly reported preparation of BSH and BSeH provides an efficient and convenient route to the preparation of key chalcogenated boron cluster building blocks for the biomedical and materials science communities.

Source: Inorganic Chemistry

DOI: 10.1021/acs.inorgchem.5c00469

Authors: Tyler A. Kerr, Yessica A. Nelson, Nicholas A. Bernier, Alexander M. Spokoyny

Institutions: University of California, Los Angeles, California NanoSystems Institute

Language: English

Topic: Boron Compounds in Chemistry

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $4,500