Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolution
Year: 2025
Type: article
Abstract: phenotype. This immunothrombolytic axis results in thrombus resolution. Together, with this immune landscape of thrombosis, we provide a valuable resource and introduce the concept of "immunothrombolysis" with broad mechanistic and translational implications at the crossroad of inflammation and thrombosis.
Source: Immunity
Authors: Kami Pekayvaz, Badr Kilani, Markus Joppich, Luke Eivers, Sophia Brambs, Viktoria Knottenberg, Sezer Akgöl, Keyang Yue, Lukas Li, Alejandro Martinez-Navarro, Rainer Kaiser, Nina Meißner, Heiko Schulz, Larissa Belz, Anastassia Akhalkatsi, Sven Stockhausen, Tonina T. Mueller, Simon Millonig, Lea Hartelt, Christoph Gold, Aleksandar Janjic, Vivien Polewka, Franziska Wendler, Augustin Droste zu Senden, Anna Titova, Alexander Leunig, Michael Voelkl, Bernd Engelmann, Moritz R. Hernandez Petzsche, Tobias Boeckh-Behrens, Thomas Liebig, Sandra Winning, Joachim Fandrey, Martin Dichgans, Wolfgang Enard, Ralf Zimmer, Steffen Tiedt, Steffen Massberg, Leo Nicolai, Konstantin Stark
Institutions: LMU Klinikum, German Centre for Cardiovascular Research, Ludwig-Maximilians-Universität München, Institut für Schlaganfall- und Demenzforschung, Pathologisches Institut, Institut für Laboratoriumsmedizin, TUM Klinikum, Technical University of Munich, Institut für Diagnostische und Interventionelle Neuroradiologie, University of Duisburg-Essen, German Center for Neurodegenerative Diseases, Munich Cluster for Systems Neurology
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $10,400
OpenAlex ID: W4409764457