Work

CHIP’ing Signal from Noise in Liquid Biopsy

Year: 2025

Type: article

Abstract: The presence of clonal hematopoiesis in cell-free DNA analysis can distort the interpretation of results and influence cancer treatment decisions. This CCR Translations discusses the importance of distinguishing the origin of cell-free DNA variants as tumoral or hematopoietic and its potential clinical implications. See related article by Magee et al., p. 2710.

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-25-0569

Authors: Elsa Bernard, Jean-Baptiste Micol

Institutions: Inserm, Université Paris-Saclay, Institut Gustave Roussy, Cellules souches hématopoïétiques et développement des hémopathies myéloïdes

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Pfizer, Servier