Work

Targeting the Odontogenic Keratocysts: Therapeutic Potential of 5-Fluorouracil Through Thymidylate Synthase Inhibition

Year: 2025

Type: article

Abstract: Odontogenic keratocysts (OKCs) are aggressive cystic lesions of the jaw with a high recurrence rate. They are benign lesions that arise from dental lamina remnants or basal cells of the overlying epithelium. Various surgical and adjunctive treatments have been explored to minimize recurrence. In this report, we review the literature elucidating the efficacy of 5-fluorouracil (5-FU) topical application for recurrent OKCs and discuss the management of an OKC with 5-FU after enucleation and a 12-month follow-up.

Source: Cureus

DOI: 10.7759/cureus.82905

Authors: G V Reddy, G. Siva Prasada Reddy, Vishnu Priyatham, John Jims Veeravalli, Srimounica Kocherlakota

Institution: Panineeya Institute of Dental Sciences & Research Centre

Language: English

Topic: Oral and Maxillofacial Pathology

Subfield: Oral Surgery

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409767266