Year: 2025
Type: article
Abstract: Four scandium(III) sulfa drug complexes were studied based on thermal, kinetic, morphological and computational investigations. The isolated solid complexes were synthesized by 1:2 molar ratios between scandium(III) chloride and four kinds of sulfa drugs; sulf-1 = sulfadimidine (1), sulf-2 = sulfanilamide (2), sulf-3 = sulfamethoxazole (3) and sulf-4 = sulfadiazine (4). The molecular formulae for the isolated complexes are [Sc(sulf-1)2(Cl)2]Cl (5), [Sc(sulf-2)2(Cl)2]Cl (6), [Sc(sulf-3)2(Cl)2]Cl (7) and [Sc(sulf-4)2(Cl)2]Cl (8). TGA thermograms for complexes (5-8) were utilized to study the different degradation steps. Moreover, the kinetic and thermodynamic functions have been calculated based on the data speculated for compounds (5-8). The surface morphology of (5-8) was studied by scanning electron microscopy (SEM). The compounds (5-8) exhibit favorable crystallinity, as X-ray powder diffraction (XRD) confirmed. The nano-scale of the samples was confirmed by the transmission electron microscopy (TEM) images. Furthermore, the DFT calculations for (1-8) were performed. The bond lengths for (5-8) are reduced or increased rather than that of free drug molecules due to complexation. Bond angles of compounds (5-8) predict the octahedral geometry (Oh) of Sc(III). The calculated vibrational spectra for compounds (5-8) were compared to the experimental IR, which may give quite differences attributed to different phases of measurement. KEY WORDS: Scandium, Sulfa-drugs, TGA, SEM, TEM, DFT, Coats-redfern, Complexes, Nano-particles Bull. Chem. Soc. Ethiop. 2025, 39(7), 1363-1380. DOI: https://dx.doi.org/10.4314/bcse.v39i7.10
Authors: Abeer A. El-Habeeb, Moamen S. Refat, Q. Mohsen, Kareem A. Asla
Institutions: Princess Nourah bint Abdulrahman University, Taif University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409768577