Work

Effect of safflower (Carthamus tinctorius) on the biochemical profile of blood serum and insulin levels in alloxan-induced diabetic rats

Year: 2025

Type: article

Abstract: Safflower or Carthamus tinctorius L. has found clinical applications in treatment of certain diseases which involve inflammation and oxidative stress.The aim of the present study was to detect the ameliorative effects of safflower on alloxan -induced tissue injury.To do so, serum samples were collected from rats exposed to alloxan (120 mg/kg/day) and a combination of alloxan and safflower extract (100 and 200 mg/kg/day).All three experimental groups were compared to the control group.The collected serum was analysed for measurement of fasting serum glucose (FSG), serum insulin level, total cholesterol (TC), triglycerides (TG), aspartate transferase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP).Safflower significantly reduced the alloxan induced increase in FSG, TG, TC, AST, ALT, and ALP.Moreover, safflower significantly reversed the alloxan induced reduction in serum insulin.Interestingly, the greater the increase in safflower dose (100 versus 200 mg/kg/day), the better the outcomes of the measured parameters.Alloxan significantly induced pancreatic and liver injury, indicated by elevated glycemic and lipid profile alongside elevated liver enzymes (AST, ALT, and ALP).These defects were significantly ameliorated by safflower extract in dose dependent manner.

Source: Regulatory Mechanisms in Biosystems

DOI: 10.15421/0225023

Authors: G. F. Mohammed, Y. A. Ali, M. A. M. Al-Jawadi, W. A. Hashim

Institution: Northern Technical University

Language: English

Topic: Natural Antidiabetic Agents Studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: gold

Estimated APC paid: $100