Work

Associations of adiponectin concentrations from birth until late adolescence with insulin resistance

Year: 2025

Type: article

Abstract: INTRODUCTION: We investigated associations of adiponectin concentrations from birth to adolescence with insulin resistance in late adolescence using data from Project Viva prospective birth cohort (Eastern Massachusetts, 1999-2002). METHODS: We conducted multivariable linear regression models between adiponectin (internal z-scores) at birth, early childhood, mid-childhood, early and late adolescence and insulin resistance in late adolescence with the homeostasis model for insulin resistance (HOMA-IR). RESULTS: In 468 children (52% female, 59% Non-Hispanic White), we observed inverse associations of adiponectin z-scores in mid-childhood (-0.16, 95% CI: -0.33, 0.01), early adolescence (-0.19, 95% CI: -0.37, -0.01) and late adolescence (-0.40, 95% CI: -0.57, -0.23) with HOMA-IR in late adolescence; these associations were attenuated after accounting for BMI z-score. When stratified by sex, we observed these associations in males, while estimates were more modest in females. CONCLUSION: Overall, starting in mid-childhood, lower adiponectin concentrations were linked with higher insulin resistance in late adolescence, with associations apparent mostly in males.

Source: Pediatric Obesity

DOI: 10.1111/ijpo.70015

Authors: Yeran Lee, Soren Harnois‐Leblanc, Sheryl L. Rifas‐Shiman, Emily Oken, Marie‐France Hivert

Institutions: Loyola University Chicago, Harvard University, Harvard Pilgrim Health Care, Massachusetts General Hospital

Language: English

Topic: Adipokines, Inflammation, and Metabolic Diseases

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Diabetes Association, Harvard Medical School, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases