Associations of maternal serum transthyretin concentration with pregnancy and birth outcomes
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: This study aims to explore the association of maternal serum transthyretin (TTR) concentrations with adverse pregnancy and birth outcomes, as well as the variations in TTR concentrations across different gestational weeks in relation to these outcomes. METHODS: This retrospective cohort study included 6,584 women who delivered at The Second Affiliated Hospital of Wenzhou Medical University between January 1, 2022 and January 30, 2024. Logistic regression and Restricted cubic spline (RCS) models were applied to evaluate the association between TTR levels and the risk of complications, based on TTR quartile analyses. Locally estimated scatter plot smoothing (LOESS) curves were performed to provide a graphical representation of the relationship between TTR levels and gestational weeks. RESULTS: Significant negative correlations were observed between maternal TTR levels and the risk of gestational diabetes mellitus (GDM), preeclampsia (PE), liver disease, anemia during pregnancy, and preterm delivery (all P < 0.001). The RCS models revealed a non-linear relationship between TTR levels and maternal comorbidities, including anemia (adjusted OR 0.992 [95% CI 0.990-0.994]; P = 0.017), liver disease (adjusted OR 0.991 [95% CI 0.988-0.994]; P < 0.001), hypothyroidism (adjusted OR 0.999 [95% CI 0.996-1.001]; P = 0.023) and preterm delivery (adjusted OR 0.986 [95% CI 0.983-0.989]; P < 0.001). The LOESS curves indicated a declining trend in TTR concentrations during the third trimester of pregnancy. CONCLUSION: Maternal TTR concentrations showed an inverse linear association with the incidence of GDM and PE. Moreover, complex non-linear relationships were identified with TTR levels and comorbidities such as liver disease, anemia, hypothyroidism during pregnancy, and preterm delivery.
Source: BMC Pregnancy and Childbirth
Authors: Hanzhi Hou, Zheyu Lu, Yushuang Zheng, Cengqi Xu, Lu Wang, Fan Wang
Institution: Wenzhou Medical University
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,290
Funders: Wenzhou Medical University, National Natural Science Foundation of China, Wenzhou Municipal Science and Technology Bureau, Fujian University of Traditional Chinese Medicine, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Medical Science and Technology Project of Zhejiang Province, Science and Technology Program of Zhejiang Province
Awards: G1308376076, G1849705635, G602057342
OpenAlex ID: W4409783369