NFAT2 promotes sorafenib resistance in hepatocellular carcinoma cells by modulating calcium ion signalling
Year: 2025
Type: article
Abstract: regulation-related proteins (p-PLCγ, p-IP3R, p-CaMKII), ER-related proteins (CPR94, CPR78), and oxidative stress-related proteins (NOX2, NOX4). NFAT2 overexpression inhibited apoptosis and enhanced cell migration, invasion, and proliferation. NFAT2 knockdown reduced tumorigenesis. Our study uncovered a mechanism by which NFAT2 increases HCC cell resistance to sorafenib by altering intracellular calcium ion signals, highlighting NFAT2 as a promising target for HCC drug therapy.
Authors: Jian Wang, Yi Bai, Xian-Yi Liu, Shuang Li, Ying Wang, Ya-Min Zhang, Zhang-Yong Hong
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,170
Award: G6387812047
OpenAlex ID: W4409790399