Transition Metal‐Catalyzed Directing Group‐Assisted Site‐Selective Di‐ Ortho CH Functionalizations via Double CH Activation
Year: 2025
Type: article
Abstract: The directing group (DG)‐assisted transition metal (TM)‐catalyzed site‐selective CH activation and functionalization has become a popular approach in the synthesis of natural products, pharmaceuticals, and late‐stage functionalization. In particular, the ortho ‐selective CH functionalization is frequently addressed. One DG generally directs the mono‐CH functionalization. However, over the years, there are some exceptional reactions that have been reported where one DG directs di‐ ortho ‐CH functionalization, offering extra functionalization in one pot. There is no generalization in this type of reaction. In this comprehensive report, the di‐ ortho ‐CH functionalization reactions reported in the recent two decades (2004–2024) are summarized, and the current status and future perspective for further modifications are provided. This discussion covers DG‐assisted site‐selective di‐ ortho ‐arylation, di‐ ortho ‐alkylation, di‐ ortho ‐alkenylation, di‐ ortho ‐alkynylation, di‐ ortho ‐cyanation, di‐ ortho ‐amination, di‐ ortho ‐thiolation/selenation, di‐ ortho ‐carbonylation, di‐ ortho ‐halogenation, di‐ ortho ‐oxygenation, and unsymmetrical di‐ ortho CH functionalization of inert aryl and heteroaryl CH bonds.
Source: Advanced Synthesis & Catalysis
Authors: Swadhin Swaraj Acharya, Padma Ranjan Rout, Rudranarayan Sutar, Chiranjib Pradhan, Bibhuti Bhusan Parida
Institution: Berhampur University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4409790591