A Comprehensive Study of Guanylate-Binding Protein Family Members as Prognostic marker in Breast Cancer
Year: 2025
Type: article
Abstract: Background: Breast cancer (BrCa) is the most prevalent tumor among women globally, aside from nonmelanoma skin malignancies.Unfortunately, many BrCa patients exhibit a poor response to immune checkpoint inhibitors (ICIs) because of a deficiency of infiltrating immune cells.Earlier research has shown that guanylatebinding protein 1 (GBP1) can modify the inhibitory properties of inflammatory cytokines on endothelial cell proliferation, immigration, and invasion.Objective: Since the fundamental functions of the GBP family in the cancerimmune cycle is uncertain, according to recent findings, the function of GBPs in BrCa was studied.However, the underlying function of the GBP family in the cancer-immunity cycle is uncertain.We decided to study GBPs' role in BrCa. Materials & Methods:We applied GEPIA, UALCAN, cBioPortal, GeneMANIA, Kaplan-Meier plotter, Human Protein Atlas, STRING, and TIMER in our analysis.Results: The study included 280 pregnant women.The mean age of the RA and control group (pregnant women without RA) was 32.4 ± 6.6 and 29.5 ± 6.7 years, respectively.The most prevalent adverse outcome was spontaneous abortion (54, 19.28%), which was significantly higher in the RA group (25% vs. 13.6%,P= 0.015).Cesarean section (24.3% vs. 10.7%,P= 0.003) and low birth weight (LBW) were both significantly higher in the RA group (15% vs. 5%, P= 0.005).RA increased the probability of spontaneous abortion, cesarean section, and LBW by more than 1.3 (odds ratio, 1.38; 95% CI, 0.45-5.46;P= 0.017), 2.2 (odds ratio, 2.24; 95% CI, 1.29-6.54;P =0.004), and 2.6 (odds ratio, 2.67; 95% CI, 1.86-7.05;P= 0.008) times, respectively.Conclusion: Our results confirmed a strong relation between the expression of GBP1/GBP2/GBP3/GBP4/GBP5/GBP6/GBP7 and the infiltration of all immune cells.Specifically, high GBP1/4/5 expression was strongly linked with increased infiltration of dendritic cells, B cells, CD4+ T cells, CD8+ T cells, and neutrophils in BrCa, whereas GBP2/3/6/7 expression showed a weaker positive correlation.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4409798871