Work

NNN Palladium(II)Pincer Complex in a Borrowing Hydrogen Process: Alkylation of Indoles

Year: 2025

Type: article

Abstract: Recently, an azine NNN–Pd(II) nonpalindromic pincer complex is generated, and its application in acceptorless dehydrogenative coupling is explored. This article establishes the application of the same pincer complex in the borrowing hydrogen process (BHP). Herein, the selective synthesis of C3 alkylated indoles (CAIs) is reported. Remarkably, this catalyst enables the synthesis of bis(indolyl)methanes (BIMs) by tuning the reaction conditions using the same substrates. The control experiments and quantum chemical analysis suggest that C3 functionalization of indole involves BHP. The formation of BIMs is an additional advantage.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202500313

Authors: Shivkanya M. Bhujbal, Aabid A. Wani, Prasad V. Bharatam

Institutions: National Institute of Pharmaceutical Education and Research, National Institute of Pharmaceutical Education and Research, GITAM University

Language: English

Topic: Asymmetric Hydrogenation and Catalysis

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: Department of Biotechnology, Ministry of Science and Technology, India

Award: G6196806735