Work

Protamine-related non-cardiogenic pulmonary edema during routine heparin reversal for cardiopulmonary bypass

Year: 2025

Type: article

Abstract: A 62-year-old male presented for coronary artery bypass graft (CABG) and aortic valve replacement (AVR). Following initiation of intravenous (IV) protamine for heparin reversal, the patient developed acute pulmonary edema characterized by reduced oxygen saturations and increasing airway pressures necessitating venoarterial extracorporeal membrane oxygenation (VA-ECMO) for lung recovery. This case report discusses the pathophysiology of protamine-related non-cardiogenic pulmonary edema (NCPE) and its comparison to typical protamine reactions. Anesthesiologists must be aware of this potentially life-threatening complication during procedures where protamine is commonly used to reverse the effects of heparin anticoagulation. Anesthesiology, Cardiac/Thoracic/Vascular Surgery

Source: Medical Reports

DOI: 10.1016/j.hmedic.2025.100205

Authors: Leslie Kim, Hai-Yen Nguyen, Taegen Senawong, Claudia Wei

Institution: Baylor College of Medicine

Language: English

Topic: Cardiac and Coronary Surgery Techniques

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,900