Work

Rare Case of Spontaneous Regression in Primary Gastric Diffuse Large B Cell Lymphoma

Year: 2025

Type: article

Abstract: The spontaneous regression (SR) of primary gastric diffuse large B-cell lymphoma (PG-DLBCL) is extremely rare. Although the mechanism of SR is unclear, the host immune response, ischemia, or changes in the tumor microenvironment may play a role. On the other hand, SR does not indicate a complete cure and residual lymphoma may remain dormant, leading to relapse. This paper presents a rare case of an 82-year-old woman with PG-DLBCL who experienced SR without treatment, followed by a short-term relapse. In the present case, the most likely mechanism was biopsy-induced ischemia and increased apoptosis. This case underscores that, in PG-DLBCL with SR, the initial endoscopic findings are the most critical reference for an accurate diagnosis and proper management, but careful long-term follow-up and monitoring are necessary, given the risk of relapse.

Source: Korean Journal of Gastroenterology

DOI: 10.4166/kjg.2024.151

Authors: Cheolung Kim, Kyung Bin Kim, Bong Eun Lee, Gwang Ha Kim, Moon Won Lee, Dong Chan Joo

Institutions: Pusan National University Hospital, Pusan National University

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $7