Microbiological profile of slow-growing non-tuberculous mycobacteria species other than Mycobacterium avium complex
Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction Mycobaterium avium complex (MAC) and Mycobacterium abscessus complex are the primary agents of non-tuberculous mycobacteria infection. However, other species within the slow-growing group can also be potentially pathogenic, although information on these species is limited. Objectives We conducted a prospective analysis of slow-growing species other than MAC, aimed at the identification and microbiological profiles of clinical samples from a tertiary hospital. The Microbiology Department of the Hospital Clinic of Barcelona, the Microbiology Laboratory of SYNLAB Laboratories, and the Microbiology Laboratory of Hospital Sant Joan de Deu participated in the study. Methods Species identification was conducted by MALDI-TOF MS and/or 16S rRNA and rpoB gene sequencing. Drug susceptibility tests (DST) were performed using the microdilution method. The results of the susceptibility profiles were compared with treatment guidelines, or the most recent literature related to each species. Results Twenty-five different species belonging to the slow-growing group were identified. The most frequently observed were M. xenopi, M. kansasii, M. gordonae, and M. marinum. In this series, M. lentiflavum presented the highest susceptibility profile, while M. simiae demonstrated the highest level of resistance. Clarithromycin, rifabutin, and amikacin demonstrated high levels of effectiveness across all species. The species most associated with infection, presented a high correlation with the clinical treatment guidelines. Conclusion A specific susceptibility profile was observed among all the species. The in vitro profiles of the most frequent species correlated with the clinical treatment guidelines, reinforcing the supporting role of DST in the design of individualized treatment for each patient.
Source: Frontiers in Microbiology
Authors: Mariana Fernandez-Pittol, Sara Batista, Sofía Narváez, Angely Román, Lorena San Nicolás, Diego Martínez, Laura Oliver, Olga González-Moreno, José Antonio Martínez, Felipe García, Rosanel Amaro-Rodríguez, Néstor Soler, Amadeu Gené, Araceli González-Cuevas, Griselda Tudó, Julian Gonzalez-Martin
Institutions: Hospital Clínic de Barcelona, Barcelona Institute for Global Health, Universitat de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red, Centro de Investigación Biomédica en Red Enfermedades Infecciosas, Hospital Sant Joan de Déu Barcelona
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funders: Centres de Recerca de Catalunya, Generalitat de Catalunya, Ministerio de Economía y Competitividad, Sociedad Española de Neumología y Cirugía Torácica, Instituto de Salud Carlos III, Departament d'Universitats, Recerca i Societat de la Informació, European Regional Development Fund, Agencia Estatal de Investigación
Awards: G1175115578, G1341303, G1622782223, G203129345, G2064873908, G2072863431, G2262748287, G2400940650, G2462415295, G2672435700, G2684465001, G2819494518, G3005324705, G300979063, G34346518, G3480869486, G3546882995, G3810626647, G410571670, G425668148, G451917667, G4526231891, G4936384890, G5080475149, G5405738834, G5539308778, G5913267992, G5967599077, G630635040, G6656126374, G69051668, G7084143925, G7232069073, G7793665899, G7851544345, G8374199100, G8430294048, G8637226926, G8696694383, G869884560, G8993044401, G929308097
OpenAlex ID: W4409825272