A high-efficiency automatic pressure-relief drug transfer device for anticancer medications with superior closed performance
Year: 2025
Type: article
Abstract: Objective: Preventing exposure to hazardous drugs is crucial for healthcare workers to avoid health risks. To mitigate healthcare workers' risks when handling hazardous drugs, we developed a novel closed-system drug-transfer device (CSTD) called CSTD(JLY). This CSTD has an automatic pressure-relief structure. Hence, it can significantly decrease the resistance in the push/pull of a piston rod if an operator transfers drugs, thereby reducing the burden on the hands of the operator during drug transfer. Methods: We investigated the closed performance of the novel CSTD (JLY) by comparing it with the performance of a syringe. We selected a simulation drug (fluorescein sodium), commonly used drugs (lansoprazole, nimodipine, and tropisetron), and a commonly used anti-cancer agent (cyclophosphamide) to conduct exposure evaluation. Results: Compared with a syringe, CSTD(JLY) could reduce drug leakage significantly. Our novel CSTD with an automatic pressure-relief structure had superior closed performance. CSTD(JLY) could solve the problem of liquid-drug leakage during drug transfer. Conclusion: This feature could reduce the exposure risk healthcare workers and patients.
Source: Frontiers in Pharmacology
Authors: Liming Xie, Guanfeng Chen, Qianqian Ouyang, Weiyan Quan, Xiaoming Xie, Xiaoling Chen, Lefan Li, Sidong Li, Rizhi Chen, Rongqiong Luo, Zhiqing Qiu
Institutions: Guangdong Medical College, Guangdong Ocean University
Language: English
Subfield: Occupational Therapy
Field: Health Professions
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4409826466