Work

Characteristics and hemolysis analysis of centrifugal blood pumps under different speed modulations

Year: 2025

Type: article

Abstract: Introduction: Constant-speed methods are widely applied and studied in rotary blood pumps. However, various speed modulation which have been used in commercial blood pump lacks validation of the ventricular assist capability and hemolysis potential. Methods: This study investigates the hydrodynamic performance and hemolysis of a rotary ventricular assist device under sinusoidal speed modulation, focusing on the combined effects of phase, baseline speed, and speed fluctuation amplitude. Results: Computational fluid dynamics (CFD) coupled with a dynamic cardiovascular model revealed that counter-phase modulation reduces hemolysis index (HI) fluctuations compared to in-phase conditions, while higher baseline speeds increase time-averaged HI due to prolonged exposure to non-physiological shear stress. Larger amplitudes expand the operational range but exacerbate HI variability. Discussion: These findings demonstrate that phase synchronization critically balances pulsatility and hemocompatibility, providing actionable insights for adaptive speed control strategies in clinical practice.

Source: Frontiers in Physiology

DOI: 10.3389/fphys.2025.1575971

Authors: Chengxuan Su, Donghai Jin, Guangmao Liu, Shulei Li, Xingmin Gui

Institutions: Beihang University, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease

Language: English

Topic: Mechanical Circulatory Support Devices

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801