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Enigmatic response of frequent use of rituximab in multidrug resistant nephrotic syndrome with focal segmental glomerulosclerosis with NPHS1 gene mutation children: genetic and pathophysiological consideration

Year: 2025

Type: article

Abstract: Childhood nephrotic syndrome due to focal segmental glomerulosclerosis (FSGS) usually refractory to multiple immunosuppressive drugs including rituximab. Nephrotic syndrome secondary to NPHS1 gene mutation also showed multidrug resistance with bad prognosis. Here, we are reporting a case who has multidrug resistant nephrotic syndrome with FSGS with NPHS1 gene mutation but responded well with frequent periodic use of rituximab.

Source: International Journal of Contemporary Pediatrics

DOI: 10.18203/2349-3291.ijcp20251106

Authors: M. Shanjida Sharmim, Afroza Begum, Delwar Hossain, Shamsun N. Shanta

Institution: Bangladesh Medical University

Language: English

Topic: Renal Diseases and Glomerulopathies

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4409827151

FWCI:

Cites: 11

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Related to: 10