Work

Sleep in disease: inflammation and chronic rhinosinusitis

Year: 2025

Type: article

Abstract: Chronic rhinosinusitis (CRS) is a common inflammatory disorder that is associated with significant quality of life (QOL) impairment, including sleep dysfunction. There are multiple factors that have been independently associated with poor sleep among this population including alterations in inflammatory mediators, rhinologic symptom interference such as nasal discharge, obstruction, and facial pain, and co-morbid conditions including asthma. While there is a high prevalence of sleep dysfunction among this population, treatment with both medical and surgical options may lead to sustained improvements in sleep. This review aims to highlight the burden of sleep dysfunction, discuss common theories regarding the etiology, and evaluate strategies that may facilitate improvement in sleep dysfunction among patients with CRS. • Sleep dysfunction is highly prevalent among patients with chronic rhinosinusitis. • Numerous factors may impact sleep in this population, including immune mediators. • Both medical and surgical treatments may improve sleep quality in these patients.

Source: Neurobiology of Sleep and Circadian Rhythms

DOI: 10.1016/j.nbscr.2025.100120

Authors: Vivek C. Pandrangi, Jeremiah A. Alt

Institutions: Oregon Health & Science University, University of Utah

Language: English

Topic: Sinusitis and nasal conditions

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,510