Year: 2025
Type: article
Abstract: Neuropathic pain is a severe form of pain that is brought on by dysfunction in the brain and is connected with a number of degenerative alterations in the nervous system. Hyperalgesia and allodynia are two of the main symptoms of pain. Many neurological diseases seen in chronic alcoholics are linked to dietary deficiencies, especially vitamin deficits that are crucial for healthy brain function. The brain may suffer from severe functional impairment and tissue damage, mostly neuronal and vascular, as a result of specific vitamin and nutritional shortages that develop in chronic alcoholics. Moreover, nutritional inadequacies in chronic alcoholics contribute to oxidative stress, metabolic dysfunction, ion channel dysfunction, and neurotransmitter dysfunction. There are numerous molecular mechanisms that contribute to the development of alcoholinduced neuropathy symptoms. A threonine/serine kinase protein kinase C (PKC) regulates various body functions like cell growth and differentiation, release of neurotransmitters, excitation of cellular membranes and in memory. It is necessary to investigate all connected pathways in order to create an effective therapy for neuropath disease.
Author: Shashidhar Mehta
Institutions: University of Delhi, Lady Hardinge Medical College
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409830198